Document 0117
 DOCN  M9490117
 TI    [The effect of trichosanthin on immunoregulatory T lymphocytes]
 DT    9411
 AU    Bi LQ; Liu JW; Song Y; Third Medical College, Norman Bethune University
       of Medical; Science, Changchun.
 SO    Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1994 Jan;14(1):18-20, 3-4.
       Unique Identifier : AIDSLINE MED/94319131
 AB    The effect of trichosanthin (TCS) on immune system has drawn attentions
       of the investigators both at home and abroad. The purpose of this study
       is to evaluate the prospects of TCS on autoimmune diseases and
       immunodeficiency diseases by detecting the immunoregulatory T
       lymphocytes (T8, 2H4, 4B4) count and cellular DNA content under the
       influence of TCS with flow cytometer using indirect immunofluorescence
       technique and lymphocyte culture in normal subjects and systemic lupus
       erythematosus patients. The results showed that the percentage of T8+
       cells decreased, 4B4+ cells increased, 2H4+ cells did not markedly
       change after adding TCS. The raise of DNA content in S stage was
       dose-dependent to TCS, especially in large doses. It is concluded that
       TCS could selectively inhibit T8+ cells and could obviously increase the
       number of 4B4+ cells. It is suggested that TCS could enhance humoral
       immunity through the ratio of immunoregulatory T cells. So TCS might
       help immunodeficiency patients such as AIDS to reestablish their immune
       system.
 DE    Adjuvants, Immunologic/PHARMACOLOGY  Adult  DNA/BIOSYNTHESIS  English
       Abstract  Female  Human  Leukocyte Count/DRUG EFFECTS  Lupus
       Erythematosus, Systemic/*IMMUNOLOGY  Male  T-Lymphocytes,
       Regulatory/*IMMUNOLOGY  Trichosanthin/*PHARMACOLOGY  JOURNAL ARTICLE

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